West Virginia Mountaineers42vs.Iowa State Cyclones won45

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Sep 27 forecast

West Virginia’s defensive collapse and repeated losses at Jack Trice give Iowa State the stronger setup, so an Iowa State victory is favored.

Both teams enter after conference-opening home losses, but West Virginia’s defensive breakdown was more severe and its recent trips to Ames have ended poorly. Iowa State also showed resilience after halftime against Utah, although its turnovers and uneven run defense leave a clear path for West Virginia. Iowa State is favored because West Virginia’s productive rushing attack can shorten the game and punish another slow Cyclones start.

Points to Iowa State

Jack Trice Stadium has been a persistent obstacle for West Virginia.
As reported September 27, 2026, West Virginia had lost its three most recent trips to Jack Trice Stadium, in 2018, 2020 and 2022.
West Virginia’s defense enters after a comprehensive breakdown.
On September 26, 2026, Oklahoma State gained 609 yards and beat West Virginia 41-24 in Morgantown.
Iowa State showed it can adjust and recover after a poor start.
On September 26, 2026, Iowa State rallied from a 24-3 halftime deficit against Utah to pull within 24-17 during the fourth quarter.

Points to West Virginia

West Virginia brings a rushing attack capable of controlling the matchup.
On September 26, 2026, West Virginia rushed for 334 yards against Oklahoma State, led by Cam Cook’s 193 yards and Mike Hawkins Jr.’s 102 yards.
Iowa State’s offense and run defense both showed vulnerabilities against Utah.
On September 26, 2026, Utah outrushed Iowa State 205-111 while Jaylen Raynor threw two interceptions in a 31-17 Cyclones loss.

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